Since the late 1990s, several social actors in Canada have been pushing for the creation of state-funded centers where people can inject illegal drugs. This paper proposes a sociological interpretation of the fact that it only took a few years for this “harm reduction” strategy to receive political consideration in Canada, a country still devoted to a prohibitionist system. The arguments by university, journalistic, and political actors in favor of such centers appear to be focused on the socio-sanitary aspect of drug use. A hygienic depoliticization has occurred and the prohibition-legalization tension has disappeared.